Melanotan II is a highly potent synthetic peptide analogue of the naturally occuring hormone α-MSH, that may elicit melanogenic,
aphrodisiac and anorectic effects through non-selective stimulation of melanocortin receptors.
Melanotan II consists of seven amino acids and is a cyclic, shortened lactam peptide hormone that
has a molar mass of 1024.180 Da (g/mol) and is comprised of the amino acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2.
The development of Melanotan II has been credited to scientists at the University of Arizona who hypothesized that
peptide would stimulate melanogenesis, a process by which the pigment cells (melanocytes) produce melanin at the
cellular level. After synthesizing and testing numerous peptides, these scientists, headed by Dr. Victor Hruby, discovered
Melanotan and deemed it not only safe, but also approximately 1,000 times more potent than natural α-MSH.
In simple terms: Melanotan II is a synthetically created peptide (small protein) that may induce melanogenesis (tanning of the skin), aphrodisiac effects (increased libido in males & females) as well as appetite suppressant effects through stimulation of certain melanocortin peptide hormone receptors in the human body.
It is known that the effects of α-MSH are mediated by melanocortin receptors. MC1R is expressed in skin cells and has a high affinity for α-MSH and is the main receptor by which α-MSH signals. Based on this fundamental information, and observations of how α-MSH impacts melanomic cells, one study has hypothesized that "α-MSH acts initially to reduce initial tumor spread, but then paradoxically protects those cells that escape from the primary tumor." As an analog of α-MSH, it is logical to believe that Melanotan II may have similar effects.
Theoretically, Melanotan II may enhance sexual function in males (erectile activity) and females (increased levels of sexual desire and genital arousal). Unlike other sexual-enhancement drugs, it is hypothesizedd that Melanotan II works at a neurological level, eliciting a more "natural" sexual response with minimal side effects. It was suggested that Melanotan II "may prove equally effective in women" as a "treatment of female sexual dysfunction. At least one study has observed that administration of Melanotan II may increase sexual desire, which should warrant further "investigation of centrally acting agents on disorders of sexual desire." A pilot Phase I clinical trial published in 1996 conducted on three males by the College of Medicine, Pharmacology Department, University of Arizona in Tucson, Arizona reported that "Melanotan II has tanning activity in humans given only 5 low doses every other day by subcutaneous injection." The side effects reported were mild nausea and a "stretching and yawning complex" that correlated with spontaneous penile erections.
Melanotan II studies conducted on laboratory mice have also demonstrated the peptides profound effect on lipid metabolism and caloric intake. Specifically, six days of administration in laboratory mice resulted in a significant reduction in body weight and fatty tissue along with a decrease in the amount of calories ingested by the mice. Moreover, it was also demonstrated that Melanotan II administration promoted an increase in the utilization of oxygen in the obese subjects. Studies have also suggested that Melanotan II administration may enhance catabolism of fat in muscle tissue and promote an improvement in cholesterol metabolism as well.
Melanotan II, commonly referred to as Melanotan 2, has garnered a reputation online as being a highly effective tanning agent. This, however, comes with a potential multitude of side effects that must not be taken lightly (see Results & Side Effects below). The best, most efficient method of administering Melanotan peptides are subcutaneous (subq) injection. Nasal sprays are inconsistent and inefficient at best. Melanotan II has not been approved for human use outside of clinical trials; however, it has been studied extensively for use in protecting against the harmful effects of ultraviolet radiation from sunlight due to its melanogenesis stimulating properties. Resultantly, it was conceived that Melanotan II could be used to stimulate skin melanogenesis and development as a photoprotective or cosmetic drug.
Additionally, Melanotan II and a similar α-MSH analogue, know as PT-141 or Bremelanotide, have been studied at length as a potential remedy for the treatment of sexual dysfunction. Theoretically, Melanotan II may enhance sexual function in males (erectile activity) and females (increased levels of sexual desire and genital arousal). Unlike other sexual-enhancement drugs, it is hypothesizedd that Melanotan II works at a neurological level, eliciting a more "natural" sexual response with minimal side effects. It was suggested that Melanotan II "may prove equally effective in women" as a "treatment of female sexual dysfunction. At least one study has observed that administration of Melanotan II may increase sexual desire, which should warrant further "investigation of centrally acting agents on disorders of sexual desire."
Uses and desired benefits amoung users include:
There are many things you will need to consider before experimenting with melanotans peptide. Cyclic alpha-MSH analogues (Melanotan II) have a wide range of peripheral effects and systemic control is always going to pose an issue in clinical research. Needless to say, Melanotan II is not an approved or regulated product.
Users will typically see an increase in pigmentation straight away while in the loading phase, users with freckles will notice them getting darker before the actual skin color changes. Tans developed using the peptides will typically last much longer than an ordinary tan, often for months at a time after the user stops getting regular sun.
Type of water to reconstitute (mix) Melanotan II:
Sterile water or Sterile Bacteriostatic Water are the most suitable diluents for Melanotan II. In many countries Bacteriostatic Water for Injection can be purchased directly from a local pharmacy without a prescription. Alternatively, Bacteriostatic Water for Injection can be purchased from a growing number of online medical supply shops.
Syringes to be used for tanning injections:
Insulin type syringes with 100 markings on the side should be used. They are readily available in any local pharmacy store and through online.
How to mix (reconstitute) the lyophilized Melanotan II peptide:
1. Remove the cap from the Melanotan II vial and the cap from the vial of Bacteriostatic Water.
2. Swab both the Melanotan II and Bacteriostatic Water exposed rubber stoppers with an alcohol wipe.
3. Using an insulin syringe, draw 1mL of Bacteriostatic Water to be injected into the Melanotan II vial.
4. Slide the inslulin syring into the Melanotan II vial on a slight angle (approximately 45 degrees). Slowly push the Bacteriostatic Water into the Melanotan II vial, do not apply excessive pressure. The water should trickle down the side of the Melanotan II vial and slowly mix with the peptide.
5. After the 1mL of water is added, gently swirl the Melanotan II vial until all peptide is disolved. Do not shake the vial.
Melanotan II Injection spot and procedure:
Melanotan II has a systemic effect regardless of where it is injected. Melanotan II should be injected subcutaneously (stomach fat). Injections should be given in different sites (rotated) each time. Depending on the spot, you can either feel nothing or you can feel slight pain. Prior to injecting clean the injection spot as well as the vial rubberstopper with an alcohol swab. Make sure there are no air bubbles in the syringe. For subcutaneous injection fully insert the needle at a 45 degree angle.
Melanotan II dosage:
Your first injection should be a very small dose, for example .2mg (200mcg). See how you react. Goal should be to feel nothing. Dose after dinner, before bed. Any dosing chart stating that you should take a high dose (according to your weight) is dated and potentially dangerous. Melanotan is a poor sunless tanner. UV (from sun or a tanning bed) light is necessary to develop a tan for most folks. Without it, almost nothing happens. In other words, NO UV = NO TAN. Melanotan use for a full month and with UV exposure, you (and your friends) will be astounded by how fast and how dark MT-II tanning results. Areas of skin that are typically sun-exposed in your day to day life will respond more readily to the effects of the melanotan peptides, take photo therapy serious with Melanotan II.
1. Melanotan II loading phase:
Melanotan II Storage guidelines:
Before reconstitution (lyophilized / freeze dried powder):
The effects of Melanotan II are dosage dependent and usually become noticeable within days. Individuals will respond differently, however some effects are generally observed by most people. When supplementing Melanotan to tan keep in mind that tanning is literally a side effect. The tanning response (melanogenesis) is, in reality, a physiological repair mechanism to UV damage of the cells (epidermis/dermis).
Desirable effects / results of Melanotan II:
Unwanted / Potentially harmful side effects of Melanotan II:
Ordering Melanotan II Online:
There a numerous online shops selling Melanotan II and related peptides PT-141 Bremelanotide and Melanotan-1. Caution must be taken when ordering from any supplier for the first time as quality and purity is of the upmost importance. Review content on the website to ensure that purity levels exceed 99% and that the peptides do not contain any fillers or other adulterants. Ask for a production (Synthesis) date to ensure the peptide is not old or potentially ineffective due to degradation.
Melanotan II details to verify before you buy:
1. Does the supplier sell additive-free and highly-purified peptides?
2. Are the peptides sold in the lyophilized powder form? - Pre-mixed peptides degrade much more rapidly.
3. Is delivery guaranteed to your location? - Local domestic sources are optimal.
4. Is the Melanotan II fresh or has it been made several months prior?
What to expect when you receive your Melanotan II:
Delivery commonly takes a short as 1-2 days (domestically) up to 2-3 weeks (if mailed internationally). Fortunately, melanotan peptides do not degrade rapidly at room temperature or above, so a delivery time of 2 weeks or less is recommended. Once your receive your purchase in the mail, examine the vial. The peptide should be in a powder form. It may be in the shape of a small puck or a few lose granules. The peptide should be white in color. Verify that the cap is attached and that the rubber stopper is not exposed or loose. Check the vial label to ensure valid expiration date (if applicable).
Use of this website: The information provided on this website is for educational and entertainment purposes only and it is not intended to take the place of your personal physician's advice. This website provides users with information related to Melanotan II and other peptides. This website does not recommend that anyone use Melanotan II without medical supervision and instruction as Melanotan II may have severe side effects. The information provided on this website has been taken from different sources and the owners of this website do not assure the accuracy of any information provided. The material and information on this web site may contain factual inaccuracies and/or typographical errors. Changes are periodically made to this web site and may be made at any time.